The UConn MD/PhD Program would like (almost two years belatedly) to congratulate Alexandra “Allie” Goetjen, a 7th year student in the program, on her receipt of a F30 Pre-Doctoral Fellowship from the NIH.
Her grant, titled “GABRA2 genetic variants and chromosome conformation in induced pluripotent stem cell-derived neural cells” aims to advance our ability to understand and treat alcohol use disorder.
Here is a lay summary from the grant (we’re not all neurogenetecists):
Alcohol use disorder is a chronic neuropsychiatric disorder with limited treatment options currently available. High prevalence of this disorder in the U.S. population presents a significant financial, emotional, and physical burden on patients, their families, and society. Early detection of individuals at increased genetic risk for developing AUD could lead to more-individualized treatment options.
NIH F30s are highly competitive fellowships for MD/PhD students awarded on the merit of the research proposal, the candidate in question, their faculty mentor, and their institutional environment.
We asked Allie to comment on her accomplishment:
This project is possible due to the patience, kindness, and mentorship I have received from Dr. Jonathan Covault. In addition, the expertise of the members of my thesis committee is invaluable. I thank Drs. Richard Lieberman and Maegan Watson for pioneering the use of iPSC-derived neural cultures in the Covault laboratory for the study of genetic and epigenetic mechanisms associated with increased risk of developing AUD. I am grateful for Kaitlin Clinton’s tireless guidance and patience along the length of this project, during the many times I have had questions when trying new techniques, gotten physically lost while trying to find something in the building, or was in need of the support of a friend when an experiment did not work the way we had expected it to. I am humbled to have the opportunity to work with the Alcohol Research Center at UConn Health. Lastly, I am grateful for the challenges, people, and places I have encountered up to this point on my journey to obtaining my dual doctorate degrees, as each has shaped me into the person I am today, and will continue to shape me into a physician-scientist eager to join the fields of academic medicine, genetics, and addiction psychiatry.
This achievement comes after an upward struggle against serious personal hardships that just could not keep Allie down. As you can tell from her commentary, her personal strength, diligence, and perseverance are surpassed only by her humility. Allie will return to the clinic this year, and aims to pursue a career as an academic Psychiatrist.