MD/PhD Students Develop Platform to Study Heart Failure

Microscopic image of fluorescently labeled cardiomyocytes by the Hinson Laboratory.

We would like to congratulate MD/PhD candidates Anthony “Tony” Pettinato, Feria Ladha, and Rachel Cohn for their publication in the American Heart Association’s journal Circulation. As members of the Hinson laboratory at Jax, students Pettinato, Ladha, and Cohn leverage powerful genetic research techniques to study cardiac dysfunction. Their paper “Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human TNNT2 Variants” provides a better understanding of how mutations in cardiac muscle proteins can lead to heart disease and failure. Beyond their study of the titular protein Troponin, these experiments illustrate a novel platform of single cell functional assays that can be used to study new drug candidates for heart disease or test patient-specific defects in a host of cardiac proteins.

For further information, see their full publication here