M.D./Ph.D. Student Publications

Listed are publications that our students, bolded, have recently authored or co-authored while part of the UConn MD-PhD Program.

2024

Karginov TA, Ménoret A, Leclair NK, Harrison AG, Chandiran K, Suarez-Ramirez JE, Yurieva M, Karlinsey K, Wang P, O'Neill RJ, Murphy PA, Adler AJ, Cauley LS, Anczuków O, Zhou B, Vella AT. Autoregulated splicing of TRA2β programs T cell fate in response to antigen-receptor stimulation. Science. 2024 Sep 13;385(6714):eadj1979. doi: 10.1126/science.adj1979. Epub 2024 Sep 13. PMID: 39265028.

Sutter PA, Willis CM, Menoret A, Nicaise AM, Sacino A, Sikkema AH, Jellison ER, Win KK, Han DK, Church W, Baron W, Vella AT, Crocker SJ. Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and FTY720 responses. Proc Natl Acad Sci U S A. 2024 Jan 30;121(5):e2306816121. doi: 10.1073/pnas.2306816121. Epub 2024 Jan 24. PMID: 38266047; PMCID: PMC10835138.

Coleman B, Casiraghi E, Callahan TJ, Blau H, Chan LE, Laraway B, Clark KB, Re'em Y, Gersing KR, Wilkins KJ, Harris NL, Valentini G, Haendel MA, Reese JT, Robinson PN. Association of post-COVID phenotypic manifestations with new-onset psychiatric disease. Transl Psychiatry. 2024 Jun 8;14(1):246. doi: 10.1038/s41398-024-02967-z. PMID: 38851761; PMCID: PMC11162470.

Sutter PA, Lavoie ER, Lombardo ET, Pinter MK, Crocker SJ. Emerging Role of Astrocyte-Derived Extracellular Vesicles as Active Participants in CNS Neuroimmune Responses. Immunol Invest. 2024 Jan;53(1):26-39. doi: 10.1080/08820139.2023.2281621. PMID: 37981468.

Morgan AT, Coleman B, Vogel AP, McNeill A, Robinson PN. Speech and language classification in the human phenotype ontology. Eur J Hum Genet. 2024 Jul 1. doi: 10.1038/s41431-024-01635-6. Epub ahead of print. PMID: 38951652.

King JS, Wan M, Wagley Y, Stestiv M, Kalajzic I, Hankenson KD, Sanjay A. Signaling pathways associated with Lgr6 to regulate osteogenesis. Bone. 2024 Jul 19:117207. doi: 10.1016/j.bone.2024.117207. Epub ahead of print. PMID: 39033993.

Gargano MA, Matentzoglu N, Coleman B... Robinson PN. The Human Phenotype Ontology in 2024: phenotypes around the world. Nucleic Acids Res. 2024 Jan 5;52(D1):D1333-D1346. doi: 10.1093/nar/gkad1005. PMID: 37953324; PMCID: PMC10767975.

Cappelletti L, Rekerle L, Fontana T, Hansen P, Casiraghi E, Ravanmehr V, Mungall CJ, Yang JJ, Spranger L, Karlebach G, Caufield JH, Carmody L, Coleman B, Oprea TI, Reese J, Valentini G, Robinson PN. Node-degree aware edge sampling mitigates inflated classification performance in biomedical random walk-based graph representation learning. Bioinform Adv. 2024 Mar 4;4(1):vbae036. doi: 10.1093/bioadv/vbae036. PMID: 38577542; PMCID: PMC10994718.

Sciarretta F, Ninni A, Zaccaria F, Chiurchiù V, Bertola A, Karlinsey K, Jia W, Ceci V, Di Biagio C, Xu Z, Gaudioso F, Tortolici F, Tiberi M, Zhang J, Carotti S, Boudina S, Grumati P, Zhou B, Brestoff JR, Ivanov S, Aquilano K, Lettieri-Barbato D. Lipid-associated macrophages reshape BAT cell identity in obesity. Cell Rep. 2024 Jul 3;43(7):114447. doi: 10.1016/j.celrep.2024.114447. Epub ahead of print. PMID: 38963761.

Ménoret A, Agliano F, Karginov TA, Hu X, Vella AT. IRAK4 is an immunological checkpoint in neuropsychiatric systemic lupus erythematosus. Sci Rep. 2024 Jul 16;14(1):16393. doi: 10.1038/s41598-024-63567-x. PMID: 39014006; PMCID: PMC11252422.

Xiao F, Nguyen NUN, Wang P, Li S, Hsu CC, Thet S, Kimura W, Luo X, Lam NT, Menendez-Montes I, Elhelaly W, Cardoso AC, Pereira AHM, Singh R, Sadayappan S, Kanchwala M, Xing C, Ladha FA, Hinson JT, Hajjar RJ, Hill JA, Sadek HA. Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis. Circulation. 2024 May 6. doi: 10.1161/CIRCULATIONAHA.122.059102. Epub ahead of print. PMID: 38708635.

de Jesus M, Chanda A, Grabauskas T, Kumar M, Kim AS. Cardiovascular disease and lung cancer. Front Oncol. 2024 Feb 12;14:1258991. doi: 10.3389/fonc.2024.1258991. PMID: 38410099; PMCID: PMC10896114.

Palko SI, Benoit MR, Yao AY, Mohan R, Yan R. ER-stress response in retinal Müller glia occurs significantly earlier than amyloid pathology in the Alzheimer's mouse brain and retina. Glia. 2024 Mar 18. doi: 10.1002/glia.24514. Epub ahead of print. PMID: 38497356.

Wright SS, Wang C, Ta A, Havira MS, Ruan J, Rathinam VA, Vanaja SK. A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis. Cell Reports. 2024 Mar 22;43(4):114004. doi: 10.1016/j.celrep.2024.114004. Epub ahead of print. PMID: 38522070.

Kumari P, Wright SS, Rathinam VA. Role of Extracellular Vesicles in Immunity and Host Defense. Immunol Invest. 2024 Jan;53(1):10-25. doi: 10.1080/08820139.2024.2312896. Epub 2024 Feb 13. PMID: 38348776.

Ghahremani S, Kanwal A, Pettinato A, Ladha F, Legere N, Thakar K, Zhu Y, Tjong H, Wilderman A, Stump WT, Greenberg L, Greenberg MJ, Cotney J, Wei CL, Hinson JT. CRISPR Activation Reverses Haploinsufficiency and Functional Deficits Caused by TTN Truncation Variants. Circulation. 2024 Jan 18. doi: 10.1161/CIRCULATIONAHA.123.063972. Epub ahead of print. PMID: 38235591.

2023

Callahan TJ, Stefanski AL, Wyrwa JM, Zeng C, Ostropolets A, Banda JM, Baumgartner WA Jr, Boyce RD, Casiraghi E, Coleman BD, Collins JH, Deakyne Davies SJ, Feinstein JA, Lin AY, Martin B, Matentzoglu NA, Meeker D, Reese J, Sinclair J, Taneja SB, Trinkley KE, Vasilevsky NA, Williams AE, Zhang XA, Denny JC, Ryan PB, Hripcsak G, Bennett TD, Haendel MA, Robinson PN, Hunter LE, Kahn MG. Ontologizing health systems data at scale: making translational discovery a reality. NPJ Digit Med. 2023 May 19;6(1):89. doi: 10.1038/s41746-023-00830-x. PMID: 37208468; PMCID: PMC10196319.

Sutter PA, Ménoret A, Jellison ER, Nicaise AM, Bradbury AM, Vella AT, Bongarzone ER, Crocker SJ. CD8+ T cell depletion prevents neuropathology in a mouse model of globoid cell leukodystrophy. J Exp Med. 2023 Sep 4;220(9):e20221862. doi: 10.1084/jem.20221862. Epub 2023 Jun 13. PMID: 37310382; PMCID: PMC10266545.

Casiraghi E, Wong R, Hall M, Coleman B, Notaro M, Evans MD, Tronieri JS, Blau H, Laraway B, Callahan TJ, Chan LE, Bramante CT, Buse JB, Moffitt RA, Stürmer T, Johnson SG, Raymond Shao Y, Reese J, Robinson PN, Paccanaro A, Valentini G, Huling JD, Wilkins KJ; N3C Consortium. A method for comparing multiple imputation techniques: A case study on the U.S. national COVID cohort collaborative. J Biomed Inform. 2023 Mar;139:104295. doi: 10.1016/j.jbi.2023.104295. Epub 2023 Jan 27. PMID: 36716983; PMCID: PMC10683778.

Angelo SJ, Anderson MG, Sutter PA, Halloran PJ, Kavanagh KR, Paro MR, Martin JE, Bookland MJ, Michelow IC, Hersh DS. Changes in the epidemiology of pediatric sinogenic and otogenic intracranial infections during the COVID-19 pandemic: a single-institution study. J Neurosurg Pediatr. 2023 May 26;32(2):231-241. doi: 10.3171/2023.4.PEDS23130. PMID: 37243559.

Deniz Derman I, Yeo M, Castaneda DC, Callender M, Horvath M, Mo Z, Xiong R, Fleming E, Chen P, Peeples ME, Palucka K, Oh J, Ozbolat IT. High-throughput bioprinting of the nasal epithelium using patient-derived nasal epithelial cells. Biofabrication. 2023 Aug 14;15(4):044103. doi: 10.1088/1758-5090/aced23. PMID: 37536321; PMCID: PMC10424246.

Yao AY, Halloran PJ, Ge Y, Singh N, Zhou J, Galske J, He W, Yan R, Hu X. Bace1 Deletion in the Adult Reverses Epileptiform Activity and Sleep-wake Disturbances in AD Mice. J Neurosci. 2023 Aug 30;43(35):6197-6211. doi: 10.1523/JNEUROSCI.2124-22.2023. Epub 2023 Aug 3. PMID: 37536983; PMCID: PMC10476643.

Puja Kumari, Swathy O. Vasudevan, Ashley J. Russo, Skylar S. Wright, Víctor Fraile-Ágreda, Dylan Krajewski, Evan R. Jellison, Ignacio Rubio, Michael Bauer, Atsushi Shimoyama, Koichi Fukase, Yuanpeng Zhang, Joel S. Pachter, Sivapriya Kailasan Vanaja & Vijay A. Rathinam Host extracellular vesicles confer cytosolic access to systemic LPS licensing non-canonical inflammasome sensing and pyroptosis. Nature Cell Biology (2023). https://doi.org/10.1038/s41556-023-01269-8
(See News & Views: Huang, Y., Zhou, R. Cytosolic transfer of circulating LPS by EVs. Nat Cell Biol (2023). https://doi.org/10.1038/s41556-023-01283-w)

Hudaiberdiev S, Taylor DL, Song W, Narisu N, Bhuiyan RM, Taylor HJ, Tang X, Yan T, Swift AJ, Bonnycastle LL, Consortium D, Chen S, Stitzel ML, Erdos MR, Ovcharenko I, Collins FS. Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits. Proc Natl Acad Sci U S A. 2023 Aug 29;120(35):e2206612120. doi: 10.1073/pnas.2206612120. Epub 2023 Aug 21. PMID: 37603758; PMCID: PMC10469333.

Sutter PA, Anderson MG, Sahyouni R, Plonsker J, Ravindra VM, Gonda DD, Levy ML, Dziugan K, Votoupal M, DeCuypere M, Leclair NK, Angelo SJ, Halloran PJ, Martin JE, Bookland MJ, Michelow IC, McKay L, Hersh DS. Anticoagulation for the treatment of septic cerebral venous sinus thrombosis in the setting of pediatric sinogenic and otogenic intracranial infections. Neurosurg Focus. 2023 Oct;55(4):E8. doi: 10.3171/2023.7.FOCUS23374. PMID: 37778041.

Kilbourn KJ, Leclair NK, Martin JE, Bookland MJ, Kureshi IU, Bulsara KR, Hersh DS. Incorporating simulation into the neurosurgical residency curriculum: a program director survey. J Neurosurg. 2023 Mar 3;139(1):286-291. doi: 10.3171/2023.1.JNS222589. PMID: 36883647.

Leclair NK, Chern J, Ahn ES, Chamis M, Paro MR, Lambert WA, Stoltz P, Hersh DS, Martin JE, Bookland MJ. Clinical metrics and tools for provider assessment and tracking of trigonocephaly. J Neurosurg Pediatr. 2023 Apr 7;32(1):82-90. doi: 10.3171/2023.2.PEDS22511. PMID: 37029682.

Shen E, Leclair NK, Herlth K, Soucy M, Renzette N, Zhuo X, Kelly K, Omerza G, Onyiuke H, McNeill I, Wolansky L, Becker K, Li L, Wu Q, Bulsara KR. DNA methylation provides diagnostic value for meningioma recurrence in clinical practice. Acta Neurochir (Wien). 2023 May;165(5):1323-1331. doi: 10.1007/s00701-023-05550-5. Epub 2023 Mar 15. PMID: 36920663.

Anderson MG, Jungbauer D, Leclair NK, Ahn ES, Stoltz P, Martin JE, Hersh DS, Bookland MJ. Incorporation of a biparietal narrowing metric to improve the ability of machine learning models to detect sagittal craniosynostosis with 2D photographs. Neurosurg Focus. 2023 Jun;54(6):E9. doi: 10.3171/2023.3.FOCUS2349. PMID: 37283444.

Anderson MG, Lambert W, Leclair N, Athar D, Martin JE, Bookland MJ, Hersh DS. Telemedicine Utilization in an Outpatient Pediatric Neurosurgical Clinic: A Prospective Survey of Patient and Family Preferences. World Neurosurg. 2023 Aug;176:e557-e568. doi: 10.1016/j.wneu.2023.05.102. Epub 2023 Jun 1. PMID: 37270096.

Xu S, Leclair NK, Angelo S, Paro M, Stoltz P, Anderson M, Martin JE, Hersh DS, Bookland MJ. Natural history of mild trigonocephalic deformities. J Neurosurg Pediatr. 2023 Jul 28;32(4):472-477. doi: 10.3171/2023.6.PEDS23201. PMID: 37548529.

Calderon A, Han C, Karma S, Wang E. Non-genetic mechanisms of drug resistance in acute leukemias. Trends Cancer. 2023 Oct 13:S2405-8033(23)00187-5. doi: 10.1016/j.trecan.2023.09.003. Epub ahead of print. PMID: 37839973.

Keuthan CJ, Karma S, Zack DJ. Alternative RNA Splicing in the Retina: Insights and Perspectives. Cold Spring Harb Perspect Med. 2023 Oct 3;13(10):a041313. doi: 10.1101/cshperspect.a041313. PMID: 36690463; PMCID: PMC10547393.

Rheaume BA, Xing J, Lukomska A, Theune WC, Damania A, Sjogren G, Trakhtenberg EF. Pten inhibition dedifferentiates long-distance axon-regenerating intrinsically photosensitive retinal ganglion cells and upregulates mitochondria-associated Dynlt1a and Lars2. Development. 2023 Apr 15;150(8):dev201644. doi: 10.1242/dev.201644. Epub 2023 Apr 24. PMID: 37039265; PMCID: PMC10163351.

Ta A, Ricci-Azevedo R, Vasudevan SO, Wright SS, Kumari P, Havira MS, Surendran Nair M, Rathinam VA, Vanaja SK. A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3. Nat Commun. 2023 Apr 11;14(1):2035. doi: 10.1038/s41467-023-37812-2. PMID: 37041208; PMCID: PMC10090168.

Ferraj A, Audano PA, Balachandran P, Czechanski A, Flores JI, Radecki AA, Mosur V, Gordon DS, Walawalkar IA, Eichler EE, Reinholdt LG, Beck CR. Resolution of structural variation in diverse mouse genomes reveals chromatin remodeling due to transposable elements. Cell Genomics 2023 https://doi.org/10.1016/j.xgen.2023.100291

Wang C, Shivcharan S, Tian T, Wright SS, Danyang M, Chang J, Li K, Song K, Xu C, Rathinam VA, Ruan J. Structural basis for GSDMB pore formation and its targeting by IpaH7.8. Nature 2023 ​​ https://doi.org/10.1038/s41586-023-05832-z

Benoit MR, Darboe M, Das B, Ge Y, Zhou J, Yao A, He W, Yan R, Hu X. Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation. Hum Mol Genet. 2023 Mar 20;32(7):1193-1207. doi: 10.1093/hmg/ddac282. PMID: 36370042; PMCID: PMC10026251.

Masison J, Mendes P. Modeling the iron storage protein ferritin reveals how residual ferrihydrite iron determines initial ferritin iron sequestration kinetics. PLoS One. 2023 Feb 6;18(2):e0281401. doi: 10.1371/journal.pone.0281401. PMID: 36745660; PMCID: PMC9901743.

Matz AJ, Qu L, Karlinsey K, Vella AT, Zhou B. Capturing the multifaceted function of adipose tissue macrophages. Front Immunol. 2023 Feb 16;14:1148188. doi: 10.3389/fimmu.2023.1148188. PMID: 36875144; PMCID: PMC9977801.

Cohn RL, Gasek NS, Kuchel GA, Xu M. The heterogeneity of cellular senescence: insights at the single-cell level. Trends Cell Biol. 2023 Jan;33(1):9-17. doi: 10.1016/j.tcb.2022.04.011. Epub 2022 May 20. PMID: 35599179; PMCID: PMC9812642.

Doherty L, Wan M, Peterson A, Youngstrom DW, King JS, Kalajzic I, Hankenson KD, Sanjay A. Wnt-associated adult stem cell marker Lgr6 is required for osteogenesis and fracture healing. Bone. 2023 Apr;169:116681. doi: 10.1016/j.bone.2023.116681. Epub 2023 Jan 25. PMID: 36708855; PMCID: PMC10015414.

Xing J*, Lukomska A*, Rheaume BA*, Kim J, Sajid MS, Damania A, Trakhtenberg EF. Post-injury born oligodendrocytes incorporate into the glial scar and contribute to the inhibition of axon regeneration. Development. 2023 Mar 27:dev.201311. doi: 10.1242/dev.201311. Epub ahead of print. PMID: 36971369.

Ménoret A, Agliano F, Karginov TA, Karlinsey KS, Zhou B, Vella AT. Antigen-specific downregulation of miR-150 in CD4 T cells promotes cell survival. Front Immunol. 2023 Jan 27;14:1102403. doi: 10.3389/fimmu.2023.1102403. PMID: 36817480; PMCID: PMC9936563.

Mason H, Rai G, Kozyr A, De Jonge N, Gliniewicz E, Berg LJ, Wald G, Dorrier C, Henderson MJ, Zakharov A, Dyson T, Audley J, Pettinato AM, Padilha EC, Shah P, Xu X, Leto TL, Simeonov A, Zarember KA, McGavern DB, Gallin JI. Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury. Redox Biol. 2023 Apr;60:102611. doi: 10.1016/j.redox.2023.102611. Epub 2023 Jan 18. PMID: 36709665; PMCID: PMC9894920.

Krishnan N, McMullan P, Yang Q, Buscarello AN, Germain-Lee EL. Prevalence of Chiari malformation type 1 is increased in pseudohypoparathyroidism type 1A and associated with aberrant bone development. PLoS One. 2023 Jan 20;18(1):e0280463. doi: 10.1371/journal.pone.0280463. PMID: 36662765; PMCID: PMC9858345.

LaGree TJ, Byrd BA, Quelle RM, Schofield SL, Mok WWK. Stimulating Transcription in Antibiotic-Tolerant Escherichia coli Sensitizes It to Fluoroquinolone and Nonfluoroquinolone Topoisomerase Inhibitors. Antimicrob Agents Chemother. 2023 Mar 23:e0163922. doi: 10.1128/aac.01639-22. Epub ahead of print. PMID: 36951560.

2022

Coleman B, Casiraghi E, Blau H, Chan L, Haendel MA, Laraway B, Callahan TJ, Deer RR, Wilkins KJ, Reese J, Robinson PN. Risk of new-onset psychiatric sequelae of COVID-19 in the early and late post-acute phase. World Psychiatry. 2022 Jun;21(2):319-320. doi: 10.1002/wps.20992. PMID: 35524622; PMCID: PMC9077621.

Reese JT, Coleman B, Chan L, Blau H, Callahan TJ, Cappelletti L, Fontana T, Bradwell KR, Harris NL, Casiraghi E, Valentini G, Karlebach G, Deer R, McMurry JA, Haendel MA, Chute CG, Pfaff E, Moffitt R, Spratt H, Singh JA, Mungall CJ, Williams AE, Robinson PN. NSAID use and clinical outcomes in COVID-19 patients: a 38-center retrospective cohort study. Virol J. 2022 May 15;19(1):84. doi: 10.1186/s12985-022-01813-2. PMID: 35570298; PMCID: PMC9107579.

Pijewski RS, Sutter PA, Duszak VA, Singh N, Yan R, Smith PP, Crocker SJ. Distinct profiles of cellular senescence-associated gene expression in the aged, diseased or injured central nervous system. Neurosci Lett. 2022 Feb 16;772:136480. doi: 10.1016/j.neulet.2022.136480. Epub 2022 Jan 29. PMID: 35093477.

McMullan P, Germain-Lee EL. Aberrant Bone Regulation in Albright Hereditary Osteodystrophy dueto Gnas Inactivation: Mechanisms and Translational Implications. Curr Osteoporos Rep. 2022 Feb;20(1):78-89. doi: 10.1007/s11914-022-00719-w. Epub 2022 Feb 28. PMID: 35226254.

Madden-Hennessey K, Gupta D, Radecki AA, Guild C, Rath A, Heinen CD. Loss of mismatch repair promotes a direct selective advantage in human stem cells. Stem Cell Reports. 2022 Dec 13;17(12):2661-2673. doi: 10.1016/j.stemcr.2022.10.009. Epub 2022 Nov 10. PMID: 36368329; PMCID: PMC9768573.

Wang B, Wang L, Gasek NS, Zhou Y, Kim T, Guo C, Jellison ER, Haynes L, Yadav S, Tchkonia T, Kuchel GA, Kirkland JL, Xu M. An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo. Nat Aging. 2021 Oct;1(10):962-973. doi: 10.1038/s43587-021-00107-6. Epub 2021 Oct 7. PMID: 35024619; PMCID: PMC8746571.

Karlinsey K, Matz A, Qu L, Zhou B. Extracellular RNAs from immune cells under obesity-a narrative review. ExRNA. 2022 Aug 30;4:18. doi: 10.21037/exrna-22-15. PMID: 36866026; PMCID: PMC9977143.

Karginov TA, Ménoret A, Vella AT. Optimal CD8+ T cell effector function requires costimulation-induced RNA-binding proteins that reprogram the transcript isoform landscape. Nat Commun. 2022 Jun 20;13(1):3540. doi: 10.1038/s41467-022-31228-0. PMID: 35725727; PMCID: PMC9209503.

Pettinato AM, Ladha FA, Zeman J, Ingrassia JJ. Spontaneous Coronary Artery Dissection Following SARS-CoV-2-Associated Multisystem Inflammatory Syndrome. Cureus. 2022 Jul 1;14(7):e26479. doi: 10.7759/cureus.26479. PMID: 35919216; PMCID: PMC9339137.

Gayen M, Benoit MR, Fan Q, Hudobenko J, Yan R. The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling. J Biol Chem. 2022 Nov;298(11):102532. doi: 10.1016/j.jbc.2022.102532. Epub 2022 Sep 24. PMID: 36162508; PMCID: PMC9626938.

Wright SS, Vanaja SK. Shigella "Osp"pression of innate immunity. Cell. 2022 Jun 23;185(13):2205-2207. doi: 10.1016/j.cell.2022.05.027. PMID: 35750030.

Ladha FA, Pettinato AM, Perrin AE. Medical student residency preferences and motivational factors: a longitudinal, single-institution perspective. BMC Med Educ. 2022 Mar 17;22(1):187. doi: 10.1186/s12909-022-03244-7. PMID: 35300656; PMCID: PMC8929265.

Li C, Phoon YP, Karlinsey K, Tian YF, Thapaliya S, Thongkum A, Qu L, Matz AJ, Cameron M, Cameron C, Menoret A, Funchain P, Song JM, Diaz-Montero CM, Tamilselvan B, Golden JB, Cartwright M, Rodriguez A, Bonin C, Vella A, Zhou B, Gastman BR. A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients. J Exp Med. 2022 Jan 3;219(1):e20202084. doi: 10.1084/jem.20202084. Epub 2021 Nov 22. PMID: 34807232; PMCID: PMC8611729.

Rosina M, Ceci V, Turchi R, Chuan L, Borcherding N, Sciarretta F, Sánchez-Díaz M, Tortolici F, Karlinsey K, Chiurchiù V, Fuoco C, Giwa R, Field RL, Audano M, Arena S, Palma A, Riccio F, Shamsi F, Renzone G, Verri M, Crescenzi A, Rizza S, Faienza F, Filomeni G, Kooijman S, Rufini S, de Vries AAF, Scaloni A, Mitro N, Tseng YH, Hidalgo A, Zhou B, Brestoff JR, Aquilano K, Lettieri-Barbato D. Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue. Cell Metab. 2022 Apr 5;34(4):533-548.e12. doi: 10.1016/j.cmet.2022.02.016. Epub 2022 Mar 18. PMID: 35305295; PMCID: PMC9039922.

Guan C, Larson PJ, Fleming E, Tikhonov AP, Mootien S, Grossman TH, Golino C, Oh J. Engineering a "detect and destroy" skin probiotic to combat methicillin-resistant Staphylococcus aureus. PLoS One. 2022 Dec 15;17(12):e0276795. doi: 10.1371/journal.pone.0276795. PMID: 36520793; PMCID: PMC9754240.

Wang L, Wang B, Gasek NS, Zhou Y, Cohn RL, Martin DE, Zuo W, Flynn WF, Guo C, Jellison ER, Kim T, Prata LGPL, Palmer AK, Li M, Inman CL, Barber LS, Al-Naggar IMA, Zhou Y, Du W, Kshitiz, Kuchel GA, Meves A, Tchkonia T, Kirkland JL, Robson P, Xu M. Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity. Cell Metab. 2022 Jan 4;34(1):75-89.e8. doi: 10.1016/j.cmet.2021.11.002. Epub 2021 Nov 22. Erratum in: Cell Metab. 2022 Jan 4;34(1):186. PMID: 34813734; PMCID: PMC8732323.

Forte E, Ramialison M, Nim HT, Mara M, Li JY, Cohn R, Daigle SL, Boyd S, Stanley EG, Elefanty AG, Hinson JT, Costa MW, Rosenthal NA, Furtado MB. Adult mouse fibroblasts retain organ-specific transcriptomic identity. Elife. 2022 Mar 16;11:e71008. doi: 10.7554/eLife.71008. PMID: 35293863; PMCID: PMC8959603.

Gasek NS, Kuchel GA, Kirkland JL, Xu M. Strategies for Targeting Senescent Cells in Human Disease. Nat Aging. 2021 Oct;1(10):870-879. doi: 10.1038/s43587-021-00121-8. Epub 2021 Oct 7. PMID: 34841261; PMCID: PMC8612694.

Larson PJ, Zhou W, Santiago A, Driscoll S, Fleming E, Voigt AY, Chun OK, Grady JJ, Kuchel GA, Robison JT, Oh J. Associations of the skin, oral and gut microbiome with aging, frailty and infection risk reservoirs in older adults. Nat Aging. 2022 Oct;2(10):941-955. doi: 10.1038/s43587-022-00287-9. Epub 2022 Oct 12. PMID: 36398033; PMCID: PMC9667708.

Pettinato AM, Ladha FA, Hinson JT. The Cardiac Sarcomere and Cell Cycle. Curr Cardiol Rep. 2022 Jun;24(6):623-630. doi: 10.1007/s11886-022-01682-9. Epub 2022 Apr 5. PMID: 35380383.

Chen I, Chung J, Vella R, Weinstock GM, Zhou Y, Jheon AH. Alterations in subgingival microbiota during full-fixed appliance orthodontic treatment-A prospective study. Orthod Craniofac Res. 2022 May;25(2):260-268. doi: 10.1111/ocr.12534. Epub 2021 Sep 25. PMID: 34538018.

Romano R, Ghahremani S, Zimmerman T, Legere N, Thakar K, Ladha FA, Pettinato AM, Hinson JT. Reading Frame Repair of TTN Truncation Variants Restores Titin Quantity and Functions. Circulation. 2022 Jan 18;145(3):194-205. doi: 10.1161/CIRCULATIONAHA.120.049997. Epub 2021 Dec 14. PMID: 34905694; PMCID: PMC8766920.

Urbanski L, Brugiolo M, Park S, Angarola BL, Leclair NK, Yurieva M, Palmer P, Sahu SK, Anczuków O. MYC regulates a pan-cancer network of co-expressed oncogenic splicing factors. Cell Rep. 2022 Nov 22;41(8):111704. doi: 10.1016/j.celrep.2022.111704. PMID: 36417849; PMCID: PMC9731204.

Martinez EC, Li J, Ataam JA, Tokarski K, Thakur H, Karakikes I, Dodge-Kafka K, Kapiloff MS. Targeting mAKAPβ expression as a therapeutic approach for ischemic cardiomyopathy. Gene Ther. 2022 Feb 1:10.1038/s41434-022-00321-w. doi: 10.1038/s41434-022-00321-w. Epub ahead of print. PMID: 35102273; PMCID: PMC9339585.

Sutter PA, Crocker SJ. Glia as antigen-presenting cells in the central nervous system. Curr Opin Neurobiol. 2022 Dec;77:102646. doi: 10.1016/j.conb.2022.102646. Epub 2022 Nov 10. PMID: 36371828.

Rouillard ME, Hu J, Sutter PA, Kim HW, Huang JK, Crocker SJ. The Cellular Senescence Factor Extracellular HMGB1 Directly Inhibits Oligodendrocyte Progenitor Cell Differentiation and Impairs CNS Remyelination. Front Cell Neurosci. 2022 Apr 28;16:833186. doi: 10.3389/fncel.2022.833186. PMID: 35573828; PMCID: PMC9095917.

Paro M, Lambert WA, Leclair NK, Romano R, Stoltz P, Martin JE, Hersh DS, Bookland MJ. Machine Learning-Driven Clinical Image Analysis to Identify Craniosynostosis: A Pilot Study of Telemedicine and Clinic Patients. Neurosurgery. 2022 May 1;90(5):613-618. doi: 10.1227/neu.0000000000001890. PMID: 35262516.

DiScipio KA, Weerasooriya S, Szczepaniak R, Hazeen A, Wright LR, Wright DL, Weller SK. Two-Metal Ion-Dependent Enzymes as Potential Antiviral Targets in Human Herpesviruses. mBio. 2022 Feb 22;13(1):e0322621. doi: 10.1128/mbio.03226-21. Epub 2022 Jan 25. PMID: 35073739; PMCID: PMC8787488.

Leclair NK, Lambert WA, Wu Q, Wolansky L, Becker K, Li L, Leishangthem L, Bulsara KR. Genomic sequencing of a pregnancy associated symptomatic meningioma of the diaphragma sellae: a case report. Br J Neurosurg. 2022 Jan 8:1-5. doi: 10.1080/02688697.2021.2024503. Epub ahead of print. PMID: 35001774. 

Pettinato AM, Yoo D, VanOudenhove J, Chen YS, Cohn R, Ladha FA, Yang X, Thakar K, Romano R, Legere N, Meredith E, Robson P, Regnier M, Cotney JL, Murry CE, Hinson JT. Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. Cell Rep. 2021 May 4;35(5):109088. doi: 10.1016/j.celrep.2021.109088. PMID: 33951429; PMCID: PMC8161465.

Larson PJ, Chong D, Fleming E, Oh J. Challenges in Developing a Human Model System for Skin Microbiome Research. J Invest Dermatol. 2021 Jan;141(1):228-231.e4. doi: 10.1016/j.jid.2020.05.096. Epub 2020 Jun 6. PMID: 32522484; PMCID: PMC7719096.

Martinek J, Lin J, Kim KI, Wang VG, Wu TC, Chiorazzi M, Boruchov H, Gulati A, Seeniraj S, Sun L, Marches F, Robson P, Rongvaux A, Flavell RA, George J, Chuang JH, Banchereau J, Palucka K. Transcriptional profiling of macrophages in situ in metastatic melanoma reveals localization-dependent phenotypes and function. Cell Rep Med. 2022 May 17;3(5):100621. doi: 10.1016/j.xcrm.2022.100621. Epub 2022 Apr 27. PMID: 35584631; PMCID: PMC9133468.

Balachandran P, Walawalkar IA, Flores JI, Dayton JN, Audano PA, Beck CR. Transposable element-mediated rearrangements are prevalent in human genomes. Nat Commun. 2022 Nov 19;13(1):7115. doi: 10.1038/s41467-022-34810-8. PMID: 36402840; PMCID: PMC9675761.

Marazzi L, Shah M, Balakrishnan S, Patil A, Vera-Licona P. NETISCE: a network-based tool for cell fate reprogramming. NPJ Syst Biol Appl. 2022 Jun 20;8(1):21. doi: 10.1038/s41540-022-00231-y. PMID: 35725577; PMCID: PMC9209484.

Wright SS, Vasudevan SO, Rathinam VA. Mechanisms and Consequences of Noncanonical Inflammasome-Mediated Pyroptosis. J Mol Biol. 2022 Feb 28;434(4):167245. doi: 10.1016/j.jmb.2021.167245. Epub 2021 Sep 16. PMID: 34537239; PMCID: PMC8844060.

Deer RR, Rock MA, Vasilevsky N, Carmody L, Rando H, Anzalone AJ, Basson MD, Bennett TD, Bergquist T, Boudreau EA, Bramante CT, Byrd JB, Callahan TJ, Chan LE, Chu H, Chute CG, Coleman BD... Robinson PN. Characterizing Long COVID: Deep Phenotype of a Complex Condition. EBioMedicine. 2021 Dec;74:103722. doi: 10.1016/j.ebiom.2021.103722. Epub 2021 Nov 25. PMID: 34839263; PMCID: PMC8613500.

Yu CI, Martinek J, Wu TC, Kim KI, George J, Ahmadzadeh E, Maser R, Marches F, Metang P, Authie P, Oliveira VKP, Wang VG, Chuang JH, Robson P, Banchereau J, Palucka K. Human KIT+ myeloid cells facilitate visceral metastasis by melanoma. J Exp Med. 2021 Jun 7;218(6):e20182163. doi: 10.1084/jem.20182163. PMID: 33857287; PMCID: PMC8056753.

Agliano F, Karginov TA, Ménoret A, Provatas A, Vella AT. Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling. iScience. 2022 Feb 15;25(3):103932. doi: 10.1016/j.isci.2022.103932. PMID: 35243268; PMCID: PMC8886054.

Schaufler C, Daigle R, Singhaviranon S, Gjertson CK, Albertsen PC, Ristau BT. How many cores are enough? Optimizing the transperineal prostate biopsy template. Urol Oncol. 2022 May;40(5):191.e1-191.e7. doi: 10.1016/j.urolonc.2021.11.026. Epub 2022 Jan 20. PMID: 35067430.

Hensel JA, Nicholas SE, Kimble AL, Nagpal AS, Omar OMF, Tyburski JD, Jellison ER, Ménoret A, Ozawa M, Rodriguez-Oquendo A, Vella AT, Murphy PA. Splice factor polypyrimidine tract-binding protein 1 (Ptbp1) primes endothelial inflammation in atherogenic disturbed flow conditions. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2122227119. doi: 10.1073/pnas.2122227119. Epub 2022 Jul 18. PMID: 35858420; PMCID: PMC9335344.

Leclair NK, Buehler A, Wu Q, Becker K, Moss IL, Bulsara KR, Onyiuke H. Pilocytic Astrocytoma Arising from the Conus Medullaris in an Adult: A Case Report. Asian J Neurosurg. 2022 Oct 12;17(3):521-526. doi: 10.1055/s-0042-1756635. PMID: 36398175; PMCID: PMC9665972.

Paro MR, Lambert WA, Leclair NK, Chakraborty AR, Angelo S, Pesante B, Stoltz P, Martin JE, Bookland MJ, Hersh DS. Family-acquired photographs for the evaluation of pediatric head shape via telemedicine: an analysis of photograph quality. Neurosurg Focus. 2022 Jun;52(6):E11. doi: 10.3171/2022.3.FOCUS2235. PMID: 35921182.

Leclair NK, Shen E, Wu Q, Wolansky L, Becker K, Li L, Bulsara KR. Landscape of genetic variants in sporadic meningiomas captured with clinical genomics. Acta Neurochir (Wien). 2022 Sep;164(9):2491-2503. doi: 10.1007/s00701-022-05316-5. Epub 2022 Jul 26. PMID: 35881312.

Leclair NK, Anczuków O. 'Poisoning' of the transcriptome by ultraconserved elements. Nat Rev Mol Cell Biol. 2022 Dec;23(12):777. doi: 10.1038/s41580-022-00527-1. PMID: 35948729; PMCID: PMC9793964.

Leclair NK, Lambert W, Roche K, Gillan E, Gell JJ, Lau CC, Wrubel G, Knopf J, Amin S, Anderson M, Martin JE, Bookland MJ, Hersh DS. Early experience with targeted therapy as a first-line adjuvant treatment for pediatric low-grade glioma. Neurosurg Focus. 2022 Dec;53(6):E15. doi: 10.3171/2022.9.FOCUS22410. PMID: 36455272.

 

2021

Byrd BA, Zenick B, Rocha-Granados MC, Englander HE, Hare PJ, LaGree TJ, DeMarco AM, Mok WWK. The AcrAB-TolC Efflux Pump Impacts Persistence and Resistance Development in Stationary-Phase Escherichia coli following Delafloxacin Treatment. Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0028121. doi: 10.1128/AAC.00281-21. Epub 2021 Jul 16. PMID: 34097492; PMCID: PMC8284433.

Rouillard ME, Sutter PA, Durham OR, Willis CM, Crocker SJ. Astrocyte-Derived Extracellular Vesicles (ADEVs): Deciphering their Influences in Aging. Aging Dis. 2021 Sep 1;12(6):1462-1475. doi: 10.14336/AD.2021.0608. PMID: 34527422; PMCID: PMC8407882.

Sutter PA, Rouillard ME, Alshawi SA, Crocker SJ. Extracellular matrix influences astrocytic extracellular vesicle function in wound repair. Brain Res. 2021 Jul 15;1763:147462. doi: 10.1016/j.brainres.2021.147462. Epub 2021 Apr 1. PMID: 33811843.

Ravanmehr V, Blau H, Cappelletti L, Fontana T, Carmody L, Coleman B, George J, Reese J, Joachimiak M, Bocci G, Hansen P, Bult C, Rueter J, Casiraghi E, Valentini G, Mungall C, Oprea TI, Robinson PN. Supervised learning with word embeddings derived from PubMed captures latent knowledge about protein kinases and cancer. NAR Genom Bioinform. 2021 Dec 8;3(4):lqab113. doi: 10.1093/nargab/lqab113. PMID: 34888523; PMCID: PMC8652379.

Fleming E, Pabst V, Scholar Z, Xiong R, Voigt AY, Zhou W, Hoyt A, Hardy R, Peterson A, Beach R, Ondouah-Nzutchi Y, Dong J, Bateman L, Vernon SD, Oh J. Cultivation of common bacterial species and strains from human skin, oral, and gut microbiota. BMC Microbiol. 2021 Oct 14;21(1):278. doi: 10.1186/s12866-021-02314-y. PMID: 34649516; PMCID: PMC8515726.

Lukomska A*, Kim J*, Rheaume BA*, Xing J, Hoyt A, Lecky E, Steidl T, Trakhtenberg EF. Developmentally upregulated transcriptional elongation factor a like 3 suppresses axon regeneration after optic nerve injury. Neurosci Lett. 2021 Nov 20;765:136260. doi: 10.1016/j.neulet.2021.136260. Epub 2021 Sep 21. PMID: 34560191; PMCID: PMC8572158.

Reilly SK, Gosai SJ, Gutierrez A, Mackay-Smith A, Ulirsch JC, Kanai M, Mouri K, Berenzy D, Kales S, Butler GM, Gladden-Young A, Bhuiyan RM, Stitzel ML, Finucane HK, Sabeti PC, Tewhey R. Direct characterization of cis-regulatory elements and functional dissection of complex genetic associations using HCR-FlowFISH. Nat Genet. 2021 Aug;53(8):1166-1176. doi: 10.1038/s41588-021-00900-4. Epub 2021 Jul 29. Erratum in: Nat Genet. 2021 Oct;53(10):1517. PMID: 34326544; PMCID: PMC8925018.

Ebrahimi-Nik H, Moussa M, Englander RP, Singhaviranon S, Michaux J, Pak H, Miyadera H, Corwin WL, Keller GLJ, Hagymasi AT, Shcheglova TV, Coukos G, Baker BM, Mandoiu II, Bassani-Sternberg M, Srivastava PK. Reversion analysis reveals the in vivo immunogenicity of a poorly MHC I-binding cancer neoepitope. Nat Commun. 2021 Nov 5;12(1):6423. doi: 10.1038/s41467-021-26646-5. PMID: 34741035; PMCID: PMC8571378.

Brennick CA, George MM, Moussa MM, Hagymasi AT, Seesi SA, Shcheglova TV, Englander RP, Keller GL, Balsbaugh JL, Baker BM, Schietinger A, Mandoiu II, Srivastava PK. An unbiased approach to defining bona fide cancer neoepitopes that elicit immune-mediated cancer rejection. J Clin Invest. 2021 Feb 1;131(3):e142823. doi: 10.1172/JCI142823. PMID: 33320837; PMCID: PMC7843235.

Das B, Singh N, Yao AY, Zhou J, He W, Hu X, Yan R. BACE1 controls synaptic function through modulating release of synaptic vesicles. Mol Psychiatry. 2021 Nov;26(11):6394-6410. doi: 10.1038/s41380-021-01166-2. Epub 2021 Jun 22. PMID: 34158621; PMCID: PMC8760050.

Hare PJ, LaGree TJ, Byrd BA, DeMarco AM, Mok WWK. Single-Cell Technologies to Study Phenotypic Heterogeneity and Bacterial Persisters. Microorganisms. 2021 Nov 1;9(11):2277. doi: 10.3390/microorganisms9112277. PMID: 34835403; PMCID: PMC8620850.

Ladha FA, Thakar K, Pettinato AM, Legere N, Ghahremani S, Cohn R, Romano R, Meredith E, Chen YS, Hinson JT. Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2. Cell Rep. 2021 Aug 10;36(6):109512. doi: 10.1016/j.celrep.2021.109512. PMID: 34380038; PMCID: PMC8447243.

McMullan P, Maye P, Yang Q, Rowe DW, Germain-Lee EL. Parental Origin of Gsα Inactivation Differentially Affects Bone Remodeling in a Mouse Model of Albright Hereditary Osteodystrophy. JBMR Plus. 2021 Nov 16;6(1):e10570. doi: 10.1002/jbm4.10570. PMID: 35079678; PMCID: PMC8771002.

Leclair NK, Knopf J, Baldwin M, Forouhar F, Onyiuke H. Rheumatoid pannus presenting as a large epidural mass in the subaxial cervical spine: A case report. Neurochirurgie. 2022 Jan;68(1):129-132. doi: 10.1016/j.neuchi.2021.02.009. Epub 2021 Mar 2. PMID: 33667534.

King VL, Leclair NK, Coulter AM, Campellone KG. The actin nucleation factors JMY and WHAMM enable a rapid Arp2/3 complex-mediated intrinsic pathway of apoptosis. PLoS Genet. 2021 Apr 19;17(4):e1009512. doi: 10.1371/journal.pgen.1009512. PMID: 33872315; PMCID: PMC8084344.

 

2020

Bargagna-Mohan P, Schultz G, Rheaume B, Trakhtenberg EF, Robson P, Pal-Ghosh S, Stepp MA, Given KS, Macklin WB, Mohan R. Corneal nonmyelinating Schwann cells illuminated by single-cell transcriptomics and visualized by protein biomarkers. J Neurosci Res. 2021 Mar;99(3):731-749. doi: 10.1002/jnr.24757. Epub 2020 Nov 16. PMID: 33197966; PMCID: PMC7894186.

Zhou Y, Al-Naggar IMA, Chen PJ, Gasek NS, Wang K, Mehta S, Kuchel GA, Yadav S, Xu M. Senolytics alleviate the degenerative disorders of temporomandibular joint in old age. Aging Cell. 2021 Jul;20(7):e13394. doi: 10.1111/acel.13394. Epub 2021 Jun 8. PMID: 34101970; PMCID: PMC8282237.

Sutter PA, Karki S, Crawley I, Singh V, Bernt KM, Rowe DW, Crocker SJ, Bayarsaihan D, Guzzo RM. Mesenchyme-specific loss of Dot1L histone methyltransferase leads to skeletal dysplasia phenotype in mice. Bone. 2021 Jan;142:115677. doi: 10.1016/j.bone.2020.115677. Epub 2020 Oct 3. PMID: 33022452; PMCID: PMC7744341.

Leclair NK, Lambert WA, Knopf J, Stoltz P, Hersh DS, Martin JE, Bookland MJ. Rate of craniometric change following suture release in patients with metopic and sagittal craniosynostosis. J Neurosurg Pediatr. 2021 Oct 1;29(1):66-73. doi: 10.3171/2021.7.PEDS21239. PMID: 34598147.

Lambert WA, Leclair NK, Knopf J, Mosha MH, Bookland MJ, Martin JE, Hersh DS. Predictors of Telemedicine Utilization in a Pediatric Neurosurgical Population During the COVID-19 Pandemic. World Neurosurg. 2021 Sep;153:e308-e314. doi: 10.1016/j.wneu.2021.06.120. Epub 2021 Jul 2. PMID: 34224882; PMCID: PMC9760262.

Kumari P, Russo AJ, Wright SS, Muthupalani S, Rathinam VA. Hierarchical cell-type-specific functions of caspase-11 in LPS shock and antibacterial host defense. Cell Rep. 2021 Apr 20;35(3):109012. doi: 10.1016/j.celrep.2021.109012. PMID: 33882312; PMCID: PMC8451177.

Willis CM, Nicaise AM, Bongarzone ER, Givogri M, Reiter CR, Heintz O, Jellison ER, Sutter PA, TeHennepe G, Ananda G, Vella AT, Crocker SJ. Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age. Sci Rep. 2020 Jan 21;10(1):828. doi: 10.1038/s41598-020-57663-x. PMID: 31964978; PMCID: PMC6972737.

Marazzi L, Gainer-Dewar A, Vera-Licona P. OCSANA+: optimal control and simulation of signaling networks from network analysis. Bioinformatics. 2020 Dec 8;36(19):4960-4962. doi: 10.1093/bioinformatics/btaa625. PMID: 32879935.

Marazzi L, Kohli P, Eastman D. Transcriptome dataset for RNA-seq analysis of axolotl embryonic oropharyngeal endoderm explants. Data Brief. 2020 Aug 4;32:106126. doi: 10.1016/j.dib.2020.106126. PMID: 32802925; PMCID: PMC7419325.

Leclair NK, Brugiolo M, Urbanski L, Lawson SC, Thakar K, Yurieva M, George J, Hinson JT, Cheng A, Graveley BR, Anczuków O. Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis. Mol Cell. 2020 Nov 19;80(4):648-665.e9. doi: 10.1016/j.molcel.2020.10.019. Epub 2020 Nov 10. PMID: 33176162; PMCID: PMC7680420.

Leclair N, Calafiore R, Wu Q, Wolansky L, Bulsara KR. Application of targeted genome sequencing to brain metastasis from non-small cell lung carcinoma: Case report. Neurochirurgie. 2020 Dec;66(6):477-483. doi: 10.1016/j.neuchi.2020.09.010. Epub 2020 Oct 19. PMID: 33091460.

Ladha FA, Stitzel ML, Hinson JT. From GWAS Association to Function: Candidate Gene Screening Within Insulin Resistance-Associated Genomic Loci Using a Preadipocyte Differentiation Model. Circ Res. 2020 Jan 31;126(3):347-349. doi: 10.1161/CIRCRESAHA.119.316405. Epub 2020 Jan 30. PMID: 31999535; PMCID: PMC7000166.

Pettinato AM, Ladha FA, Mellert DJ, Legere N, Cohn R, Romano R, Thakar K, Chen YS, Hinson JT. Development of a Cardiac Sarcomere Functional Genomics Platform to Enable Scalable Interrogation of Human TNNT2 Variants. Circulation. 2020 Dec 8;142(23):2262-2275. doi: 10.1161/CIRCULATIONAHA.120.047999. Epub 2020 Oct 7. PMID: 33025817; PMCID: PMC7722228.

Fan Q, He W, Gayen M, Benoit MR, Luo X, Hu X, Yan R. Activated CX3CL1/Smad2 Signals Prevent Neuronal Loss and Alzheimer's Tau Pathology-Mediated Cognitive Dysfunction. J Neurosci. 2020 Jan 29;40(5):1133-1144. doi: 10.1523/JNEUROSCI.1333-19.2019. Epub 2019 Dec 10. PMID: 31822518; PMCID: PMC6989010.

Zhou W, Spoto M, Hardy R, Guan C, Fleming E, Larson PJ, Brown JS, Oh J. Host-Specific Evolutionary and Transmission Dynamics Shape the Functional Diversification of Staphylococcus epidermidis in Human Skin. Cell. 2020 Feb 6;180(3):454-470.e18. doi: 10.1016/j.cell.2020.01.006. Epub 2020 Jan 30. PMID: 32004459; PMCID: PMC7192218.

Srivastava A, Das B, Yao AY, Yan R. Metabotropic Glutamate Receptors in Alzheimer's Disease Synaptic Dysfunction: Therapeutic Opportunities and Hope for the Future. J Alzheimers Dis. 2020;78(4):1345-1361. doi: 10.3233/JAD-201146. PMID: 33325389; PMCID: PMC8439550.

Agliano F, Karlinsey KS, Ragazzi M, Ménoret A, Vella AT. A benzimidazole inhibitor attenuates sterile inflammation induced in a model of systemic autoinflammation in female mice. Sci Rep. 2020 Jul 21;10(1):12100. doi: 10.1038/s41598-020-68985-1. PMID: 32694575; PMCID: PMC7374700.

Muñoz CX, Johnson EC, Kunces LJ, McKenzie AL, Wininger M, Butts CL, Caldwell A, Seal A, McDermott BP, Vingren J, Colburn AT, Wright SS, Iii VL, Armstrong LE, Lee EC. Impact of Nutrient Intake on Hydration Biomarkers Following Exercise and Rehydration Using a Clustering-Based Approach. Nutrients. 2020 Apr 30;12(5):1276. doi: 10.3390/nu12051276. PMID: 32365848; PMCID: PMC7282025.

Goetjen A, Watson M, Lieberman R, Clinton K, Kranzler HR, Covault J. Induced pluripotent stem cell reprogramming-associated methylation at the GABRA2 promoter and chr4p12 GABAA subunit gene expression in the context of alcohol use disorder. Am J Med Genet B Neuropsychiatr Genet. 2020 Dec;183(8):464-474. doi: 10.1002/ajmg.b.32824. Epub 2020 Oct 7. PMID: 33029895; PMCID: PMC8022112.

 

2019

Cohn R, Thakar K, Lowe A, Ladha FA, Pettinato AM, Romano R, Meredith E, Chen YS, Atamanuk K, Huey BD, Hinson JT. A Contraction Stress Model of Hypertrophic Cardiomyopathy due to Sarcomere Mutations. Stem Cell Reports. 2019 Jan 8;12(1):71-83. doi: 10.1016/j.stemcr.2018.11.015. Epub 2018 Dec 13. PMID: 30554920; PMCID: PMC6335568.

Park S, Brugiolo M, Akerman M, Das S, Urbanski L, Geier A, Kesarwani AK, Fan M, Leclair N, Lin KT, Hu L, Hua I, George J, Muthuswamy SK, Krainer AR, Anczuków O. Differential Functions of Splicing Factors in Mammary Transformation and Breast Cancer Metastasis. Cell Rep. 2019 Nov 26;29(9):2672-2688.e7. doi: 10.1016/j.celrep.2019.10.110. PMID: 31775037; PMCID: PMC6936330.

Chae YK, Viveiros P, Lopes G, Sukhadia B, Sheikh MM, Saravia D, Florou V, Sokol ES, Frampton GM, Chalmers ZR, Ali SM, Ross JS, Chang S, Wang S, Chiec L, Rahbari A, Mohindra N, Villaflor V, Shin SH, Oh M, Anker J, Park LC, Wang V, Chuang J, Park W. Clinical and Immunological Implications of Frameshift Mutations in Lung Cancer. J Thorac Oncol. 2019 Oct;14(10):1807-1817. doi: 10.1016/j.jtho.2019.06.016. Epub 2019 Jun 22. PMID: 31238177.

Dodge-Kafka K, Gildart M, Tokarski K, Kapiloff MS. mAKAPβ signalosomes - A nodal regulator of gene transcription associated with pathological cardiac remodeling. Cell Signal. 2019 Nov;63:109357. doi: 10.1016/j.cellsig.2019.109357. Epub 2019 Jul 9. PMID: 31299211; PMCID: PMC7197268.

Weerasooriya S, DiScipio KA, Darwish AS, Bai P, Weller SK. Herpes simplex virus 1 ICP8 mutant lacking annealing activity is deficient for viral DNA replication. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):1033-1042. doi: 10.1073/pnas.1817642116. Epub 2018 Dec 31. PMID: 30598436; PMCID: PMC6338833.

Al-Naggar IM, Hardy CC, Taweh OG, Grabauskas T, Mulkey DK, Kuchel GA, Smith PP. HCN as a Mediator of Urinary Homeostasis: Age-Associated Changes in Expression and Function in Adrenergic Detrusor Relaxation. J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):325-329. doi: 10.1093/gerona/gly137. PMID: 30124776; PMCID: PMC6376092.

2018

Urbanski LM, Leclair N, Anczuków O. Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics. Wiley Interdiscip Rev RNA. 2018 Jul;9(4):e1476. doi: 10.1002/wrna.1476. Epub 2018 Apr 25. PMID: 29693319; PMCID: PMC6002934.

Wang VG, Kim H, Chuang JH. Whole-exome sequencing capture kit biases yield false negative mutation calls in TCGA cohorts. PLoS One. 2018 Oct 3;13(10):e0204912. doi: 10.1371/journal.pone.0204912. PMID: 30281678; PMCID: PMC6169918.

Choudhary S, Santone E, Yee SP, Lorenzo J, Adams DJ, Goetjen A, McCarthy MB, Mazzocca AD, Pilbeam C. Continuous PTH in Male Mice Causes Bone Loss Because It Induces Serum Amyloid A. Endocrinology. 2018 Jul 1;159(7):2759-2776. doi: 10.1210/en.2018-00265. PMID: 29757436; PMCID: PMC6692876.

Kalsner L, Twachtman-Bassett J, Tokarski K, Stanley C, Dumont-Mathieu T, Cotney J, Chamberlain S. Genetic testing including targeted gene panel in a diverse clinical population of children with autism spectrum disorder: Findings and implications. Mol Genet Genomic Med. 2018 Mar;6(2):171-185. doi: 10.1002/mgg3.354. Epub 2017 Dec 21. PMID: 29271092; PMCID: PMC5902398.

Rheaume BA, Jereen A, Bolisetty M, Sajid MS, Yang Y, Renna K, Sun L, Robson P, Trakhtenberg EF. Single cell transcriptome profiling of retinal ganglion cells identifies cellular subtypes. Nat Commun. 2018 Jul 17;9(1):2759. doi: 10.1038/s41467-018-05134-3. Erratum in: Nat Commun. 2018 Aug 7;9(1):3203. PMID: 30018341; PMCID: PMC6050223.

 

2016

Choudhary S, Goetjen A, Estus T, Jacome-Galarza CE, Aguila HL, Lorenzo J, Pilbeam C. Serum Amyloid A3 Secreted by Preosteoclasts Inhibits Parathyroid Hormone-stimulated cAMP Signaling in Murine Osteoblasts. J Biol Chem. 2016 Feb 19;291(8):3882-94. doi: 10.1074/jbc.M115.686576. Epub 2015 Dec 23. PMID: 26703472; PMCID: PMC4759168.